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Article

The familial Mediterranean fever protein, pyrin, associates with microtubules and colocalizes with actin filaments.

Blood - 1 Aug 2001

Mansfield E, Chae J J, Komarow H D, Brotz T M, Frucht D M, Aksentijevich I, Kastner D L

Abstract excerpt

Familial Mediterranean fever (FMF) is a recessive disorder characterized by episodes of fever and intense inflammation. FMF attacks are unique in their sensitivity to the microtubule inhibitor colchicine, contrasted with their refractoriness to the anti-inflammatory effects of glucocorticoids. Th...

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Source

Identifiers

PMID: 11468188
DOI: 10.1182/blood.v98.3.851

Genes

MEFV

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11468188-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The familial Mediterranean fever protein, pyrin, associates with microtubules and colocalizes with actin filaments.PMID 11468188Read ↗

Hematopoietic-specific expression of MEFV, the gene mutated in familial Mediterranean fever, and subcellular localization of its corresponding protein, pyrinSemantic proximity Read ↗

The familial mediterranean fever protein interacts and colocalizes with a putative Golgi transporter.Semantic proximity Read ↗

The effect of colchicine on pyrin and pyrin interacting proteins.Semantic proximity Read ↗

Pyrin, product of the MEFV locus, interacts with the proapoptotic protein, Siva.Semantic proximity Read ↗

The pyrin inflammasome aggravates inflammatory cell migration in patients with familial Mediterranean fever.Semantic proximity Read ↗

The immunological function of familial Mediterranean fever disease protein PyrinSemantic proximity Read ↗

Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation.Semantic proximity Read ↗

The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production.Semantic proximity Read ↗

Familial Mediterranean fever mutations are hypermorphic mutations that specifically decrease the activation threshold of the Pyrin inflammasome.Semantic proximity Read ↗

Mutations in the B30.2 and the central helical scaffold domains of pyrin differentially affect inflammasome activation.Semantic proximity Read ↗

The pharmacologic basis of treatment with colchicine in children with familial Mediterranean fever.Semantic proximity Read ↗

Pyrin binds the PSTPIP1/CD2BP1 protein, defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathway.Semantic proximity Read ↗

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