Article
The pharmacologic basis of treatment with colchicine in children with familial Mediterranean fever.
European review for medical and pharmacological sciences - 1 Jan 2000
Rigante D, La Torraca I, Avallone L, Pugliese A L, Gaspari S, Stabile A
Abstract excerpt
Familial Mediterranean fever (FMF) is the prototype of auto-inflammatory disorders and is ethnically restricted to people living in the Mediterranean basin and Middle-East. Pyrin, the protein product of the FMF gene, expressed in myeloid cells and fibroblasts, interacts with the cytoskeletal machinery and may modulate leukocyte effector functions. At present colchicine, an alkaloid with antimitotic activity...
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