Article
Adenosine triphosphate-binding cassette superfamily transporter gene expression in severe male infertility.
Biology of reproduction - 1 Aug 2001
Larriba S, Bassas L, Egozcue S, Giménez J, Ramos M D, Briceño O, Estivill X, Casals T
Abstract excerpt
Cystic fibrosis transmembrane regulator (CFTR), multidrug-resistant (MDR)1, and multidrug resistance-associated (MRP) proteins belong to the ATP-binding cassette (ABC) transporter superfamily. A compensatory regulation of MDR1 and CFTR gene expression has been observed in CFTR knockout rodent intestine and in an epithelial cell line of human colon, whereas a high homology and similar anion binding site are shared...
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