Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of SLC9A3 decreases CFTR protein and causes obstructed azoospermia in mice.

PLoS genetics - 1 Apr 2017

Wang Ya-Yun, Lin Ying-Hung, Wu Yi-No, Chen Yen-Lin, Lin Yung-Chih, Cheng Chiao-Yin, Chiang Han-Sun

Abstract excerpt

Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause cystic fibrosis (CF) and are associated with congenital bilateral absence of the vas deferens (CBAVD), which is the major cause of infertility in male patients with CF. However, most Taiwanese patients with CBAVD do not carry major CFTR mutations. Some patients have a single copy deletion of the solute carrier family 9 isoform...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cystic Fibrosis Transmembrane Conductance Regulator
Share to Gene Expression Regulation, Developmental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Infertility, Male

Share to Mice, Knockout

Share to Oligospermia

Share to Pancreatic Ducts

Share to Respiratory Tract Infections

Share to Sodium-Hydrogen Exchangers

Source

Open in PubMed Open full text

Identifiers

PMID: 28384194
DOI: 10.1371/journal.pgen.1006715
PMCID: PMC5398719

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of SLC9A3 decreases CFTR protein and causes obstructed azoospermia in mice.PMID 28384194Read ↗

Slc26a3 deficiency is associated with epididymis dysplasia and impaired sperm fertilization potential in the mouse.Semantic proximity Read ↗

Expression of SLC26A3, CFTR and NHE3 in the human male reproductive tract: role in male subfertility caused by congenital chloride diarrhoeaSemantic proximity Read ↗

Swine models of cystic fibrosis reveal male reproductive tract phenotype at birth.Semantic proximity Read ↗

Loss of Adgra3 causes obstructive azoospermia with high penetrance in male miceSemantic proximity Read ↗

Loss-of-function CFTR p.G970D missense mutation might cause congenital bilateral absence of the vas deferens and be associated with impaired spermatogenesis.Semantic proximity Read ↗

Congenital bilateral absence of the vas deferens as an atypical form of cystic fibrosis: reproductive implications and genetic counselingSemantic proximity Read ↗

Regulation of male fertility by CFTR and implications in male infertility.Semantic proximity Read ↗

Congenital Bilateral Absence of the Vas DeferensSemantic proximity Read ↗

CFTR Regulation of Aquaporin-Mediated Water Transport: A Target in Male Fertility.Semantic proximity Read ↗

Morphological changes in the vas deferens and expression of the cystic fibrosis transmembrane conductance regulator (CFTR) in control, deltaF508 and knock-out CFTR mice during postnatal life.Semantic proximity Read ↗

[Gene mutations in congenital bilateral absence of the vas deferens: An update].Semantic proximity Read ↗

Genetics of CFTR and male infertilitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.