Article
Molecular biology of neuroblastoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Jul 1999
Maris J M, Matthay K K
Abstract excerpt
UNLABELLED: PURPOSE AND RESULTS: Neuroblastoma, the most common solid extracranial neoplasm in children, is remarkable for its clinical heterogeneity. Complex patterns of genetic abnormalities interact to determine the clinical phenotype. The molecular biology of neuroblastoma is characterized by somatically acquired genetic events that lead to gene overexpression (oncogenes), gene inactivation (tumor suppressor...
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