Article
Mismatched human leukocyte antigen alleles protect against heterosexual HIV transmission.
Journal of acquired immune deficiency syndromes (1999) - 1 Jul 2001
Lockett S F, Robertson J R, Brettle R P, Yap P L, Middleton D, Leigh Brown A J
Abstract excerpt
Genetic variation at the human leukocyte antigen (HLA) loci has been shown to be an important risk factor for progression to HIV disease, but its significance in infection is less well understood. We have investigated its role in HIV transmission in a cohort of individuals at risk for heterosexual infection. Analysis of over 80 individuals revealed that that the degree of concordance at HLA A, B, and DR loci...
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