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Article

The Viral Interferon Regulatory Factors of KSHV: Immunosuppressors or Oncogenes?

1 Jan 2011

Abstract excerpt

Kaposi's sarcoma-associated herpesvirus (KSHV) is a large double-stranded DNA gammaherpesvirus, and the etiological agent for three human malignancies: Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. To establish and maintain infection, KSHV has evolved unique mechanisms to evade the host immune response. Cellular interferon regulatory factors (IRFs) are a critical part of the...

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PMID: 22566809
DOI: 10.3389/fimmu.2011.00019

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