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Increased expression of mitochondrial transcription factor A and nuclear respiratory factor‐1 in skeletal muscle from aged human subjects

10 Jul 2001

Abstract excerpt

The expression of two factors involved in the nuclear-mitochondrial crosstalk, namely the mitochondrial transcription factor A (TFAM) and the nuclear respiratory factor-1 (NRF-1), was studied in human skeletal muscle biopsies of young and aged subjects. Aged subjects presented a 2.6-fold and an 11-fold increase of the levels of TFAM protein and TFAM mRNA, respectively. The increased expression of TFAM was...

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PMID: 11457459
DOI: 10.1016/s0014-5793(01)02628-x

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