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Article

Effect of omeprazole on the pharmacokinetics of moclobemide according to the genetic polymorphism of CYP2C19.

Clinical pharmacology and therapeutics - 1 Apr 2001

Yu K S, Yim D S, Cho J Y, Park S S, Park J Y, Lee K H, Jang I J, Yi S Y, Bae K S, Shin S G

Abstract excerpt

BACKGROUND: Moclobemide, an antidepressant with selective monoamine oxidase-A inhibitory action, is known to be metabolized by CYP2C19 and is also reported to be an inhibitor of CYP2C19, CYP2D6, and CYP1A2. To confirm the involvement of CYP2C19, we performed a pharmacokinetic interaction study. METHODS: The effect of omeprazole on the pharmacokinetics of moclobemide was studied in 16 healthy volunteers. The...

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Identifiers

PMID: 11309556
DOI: 10.1067/mcp.2001.114231

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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