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Article

Molecular dynamics and intracellular signaling of the TNF-R1 with the R92Q mutation.

Journal of neuroimmunology - 15 Dec 2015

Agulló Luis, Malhotra Sunny, Fissolo Nicolás, Montalban Xavier, Comabella Manuel

Abstract excerpt

The tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A) gene encodes the TNF-R1, one of the main TNF receptors that mediates its inflammatory actions. In a recent study, serum levels of the soluble TNF-R1 and mRNA levels of the full-length receptor were found to be significantly increased in multiple sclerosis (MS) patients carrying the R92Q mutation. Interestingly, R92Q-mutated patients were younger...

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Identifiers

PMID: 26616867
DOI: 10.1016/j.jneuroim.2015.10.003

Genes

TNF
CASP3
TRAF2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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