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Article

Alanine-scanning mutagenesis of Aspergillus gamma-tubulin yields diverse and novel phenotypes.

Molecular biology of the cell - 1 Jul 2001

Jung M K, Prigozhina N, Oakley C E, Nogales E, Oakley B R

Abstract excerpt

We have created 41 clustered charged-to-alanine scanning mutations of the mipA, gamma-tubulin, gene of Aspergillus nidulans and have created strains carrying these mutations by two-step gene replacement and by a new procedure, heterokaryon gene replacement. Most mutant alleles confer a wild-type phenotype, but others are lethal or conditionally lethal. The conditionally lethal alleles exhibit a variety of...

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Identifiers

PMID: 11452008
DOI: 10.1091/mbc.12.7.2119
PMCID: PMC55667

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Source receipt: pubmed, retrieved 7 Sept 2026.

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