Expression of the Ca ²⁺ -Activated Chloride Channel Genes <i>CLCA1</i> and <i>CLCA2</i> Is Downregulated in Human Colorectal Cancer

Abstract excerpt

The role of ion channels in carcinogenesis and tumor progression remains unclear. We have used suppression subtractive hybridization of mRNA from paired normal colon epithelium and tumor, followed by quantitative kinetic RT-PCR, to demonstrate that the transcription of two members of a novel Ca(2+)-dependent chloride channel family, CLCA1 and CLCA2, was significantly downregulated in approximately 80% of...

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