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Article

Expression of Voltage-Gated Chloride Channels in Human Glioma Cells

2 Jul 2003

Abstract excerpt

Voltage-gated chloride channels have recently been implicated as being important for cell proliferation and invasive cell migration of primary brain tumors cells. In the present study we provide several lines of evidence that glioma Cl- currents are primarily mediated by ClC-2 and ClC-3, two genes that belong to the ClC superfamily. Transcripts for ClC-2 thru ClC-7 were detected in a human glioma cell line by...

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PMID: 12843258
DOI: 10.1523/jneurosci.23-13-05572.2003

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