Article
Maternal susceptibility locus for obstetric cholestasis maps to chromosome region 2p13 in Finnish patients.
Scandinavian journal of gastroenterology - 1 Jul 2001
Heinonen S, Eloranta M L, Heiskanen J, Punnonen K, Helisalmi S, Mannermaa A, Hiltunen M
Abstract excerpt
BACKGROUND: Obstetric cholestasis, attributed to maternal hypersensitivity to estrogens, is a pregnancy-specific disorder characterized by pruritus and biochemical cholestasis in the second or third trimester of pregnancy. The pathophysiology of the disorder is incompletely understood, but the familial nature of the disease has long been recognized. Carriership of long-chain 3-hydroxyacyl-coenzyme A dehydrogenase...
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