Article
Genetic evidence of heterogeneity in intrahepatic cholestasis of pregnancy.
Gut - 1 Jul 2003
Savander M, Ropponen A, Avela K, Weerasekera N, Cormand B, Hirvioja M-L, Riikonen S, Ylikorkala O, Lehesjoki A-E, Williamson C, Aittomäki K
Abstract excerpt
BACKGROUND AND AIMS: The aim of this study was to investigate the genetic aetiology of intrahepatic cholestasis of pregnancy (ICP) and the impact of known cholestasis genes (BSEP, FIC1, and MDR3) on the development of this disease. PATIENTS AND METHODS: Sixty nine Finnish ICP patients were prospectively interviewed for a family history of ICP, and clinical features were compared in patients with familial ICP...
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