Article
Experimentally-derived haplotypes substantially increase the efficiency of linkage disequilibrium studies.
Nature genetics - 1 Aug 2001
Douglas J A, Boehnke M, Gillanders E, Trent J M, Gruber S B
Abstract excerpt
The study of complex genetic traits in humans is limited by the expense and difficulty of ascertaining populations of sufficient sample size to detect subtle genetic contributions to disease. Here we introduce an application of a somatic cell hybrid construction strategy called conversion that maximizes the genotypic information from each sampled individual. The approach permits direct observation of individual...
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