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Article

DRPLA: recent advances in research using transgenic mouse models.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2013

Suzuki Kazushi, Sato Toshiya, Yamada Mitsunori, Takahashi Hitoshi, Tsuji Shoji

Abstract excerpt

Dentatorubral-pallidoluysian atrophy (DRPLA) is one form of trinucleotide repeat disease, which has a high prevalence rate in the Japanese population. Our group established DRPLA transgenic mice harboring a single copy of a full-length human mutant DRPLA gene with 76 CAG repeats (Q76 mice). Q76 mice showed no obvious neurological phenotype but showed somatic and intergenerational instabilities of CAG repeats...

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Identifiers

PMID: 23754232
DOI: 10.1007/978-1-62703-411-1_18

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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