Article
The relationship between a polymorphism in CYP17 with plasma hormone levels and prostate cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jul 2001
Haiman C A, Stampfer M J, Giovannucci E, Ma J, Decalo N E, Kantoff P W, Hunter D J
Abstract excerpt
The A2 allele of the CYP17 gene has been thought to be associated with increased functional activity of this steroidogenic enzyme. Consequently, the A2 allele has been examined as a biomarker of individual susceptibility to hormone-related diseases among men and women. We prospectively assessed the association between the A2 allele of CYP17 and prostate cancer risk among 590 cases and 782 controls in a...
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