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Article

Intravenous and isolated limb perfusion delivery of wild type and a tumor-selective replicating mutant vaccinia virus in nonhuman primates.

Human gene therapy - 1 Jan 2006

Naik Arpana M, Chalikonda Sricharan, McCart J Andrea, Xu Hui, Guo Z Sheng, Langham Gregory, Gardner Donald, Mocellin Simone, Lokshin Anna E, Moss Bernard, Alexander H Richard, Bartlett David L

Abstract excerpt

In this study we examine the safety, feasibility, and biodistribution of a tumor-selective mutant vaccinia (vvDD) and wild-type WR (vF13) vaccinia after delivery via intradermal or intravenous infection or isolated limb perfusion (ILP) in rhesus macaques. By intradermal inoculation, 10(6) PFU of vvDD caused a minimal skin reaction whereas vF13 caused marked erythema and necrosis with a peak indurated area of 108...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16409123
DOI: 10.1089/hum.2006.17.31

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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