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Article

Evaluation of linkage disequilibrium between chromosome 22q11 single nucleotide polymorphisms in a large outbred population.

American journal of medical genetics - 8 Mar 2002

Shaw Sarah H, Hutchison Don, Saiz Robert, Abel Ken, DeLisi Lynn E, Schork Nicholas J, Sherrington Robin

Abstract excerpt

To assess the utility of linkage disequilibrium (LD) as a tool for fine-mapping disease genes in non-isolated populations, we have assessed the linkage disequilibrium strength among a series of single nucleotide polymorphisms (SNPs) in an approximate 1 Mb region of human chromosome 22q11. Nineteen random SNPs were discovered and tested across this region with an average spacing of 57 kb (range=1.4-289 kb). These...

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PMID: 11857583
DOI: 10.1002/ajmg.10151

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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