Article
Probing the mechanism of a cyanobacterial Delta9 fatty acid desaturase from Spirulina platensis C1 (Arthrospira sp. PCC 9438).
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology - 1 Jul 2001
Meesapyodsuk D, Reed D W, Cheevadhanarak S, Deshnium P, Covello P S
Abstract excerpt
The initial and rate determining step in the mechanism of fatty acid desaturases has been proposed to be breakage of one of the C&z.sbnd;H bonds at the site of the incipient double bond. This has been investigated and supported for a number of eukaryotic fatty acid desaturases through the use of kinetic isotope effect experiments with deuterated substrates. In order to probe the reaction catalyzed by the...
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