Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Plate-based dormancy culture system for Mycobacterium smegmatis and isolation of metronidazole-resistant mutants.

FEMS microbiology letters - 25 Jun 2001

Lim A, Dick T

Abstract excerpt

Mycobacterium smegmatis is an obligate aerobe. However, growth analyses in oxygen-limited liquid cultures have shown that the bacillus is able to survive anoxia with a half-life of 4 days by shifting down to a drug-resistant, dormant state. Metronidazole is the first lead against dormant bacilli and shows selective toxicity for this physiological state. Here, we report a plate-based dormancy culture system...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to Culture Media
Share to Drug Resistance, Microbial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Metronidazole

Share to Mutation

Share to Mycobacterium smegmatis

Share to Selection, Genetic

Source

Identifiers

PMID: 11425478
DOI: 10.1111/j.1574-6968.2001.tb10718.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Plate-based dormancy culture system for Mycobacterium smegmatis and isolation of metronidazole-resistant mutants.PMID 11425478Read ↗

Antimicrobial activity against Mycobacterium tuberculosis under in vitro lipid-rich dormancy conditions.Semantic proximity Read ↗

Characterization of a Mycobacterium smegmatis uvrA mutant impaired in dormancy induced by hypoxia and low carbon concentration.Semantic proximity Read ↗

Targeting dormant phenotype acquired mycobacteria using natural products by exploring its important targets: In vitro and in silico studies.Semantic proximity Read ↗

A novel in vitro multiple-stress dormancy model for Mycobacterium tuberculosis generates a lipid-loaded, drug-tolerant, dormant pathogen.Semantic proximity Read ↗

Bridging the gap between viable but non-culturable and antibiotic persistent bacteria.Semantic proximity Read ↗

Survival of hypoxia-induced dormancy is not a common feature of all strains of the Mycobacterium tuberculosis complex.Semantic proximity Read ↗

Mycobacterium bovis BCG response regulator essential for hypoxic dormancy.Semantic proximity Read ↗

Relationship between the Viable but Nonculturable State and Antibiotic Persister Cells.Semantic proximity Read ↗

Letting Sleeping<i>dos</i>Lie: Does Dormancy Play a Role in Tuberculosis?Semantic proximity Read ↗

Profiling the Proteome of Mycobacterium tuberculosis during Dormancy and ReactivationSemantic proximity Read ↗

A Proteomic Signature of Dormancy in the Actinobacterium Micrococcus luteusSemantic proximity Read ↗

Individuality, phenotypic differentiation, dormancy and ‘persistence’ in culturable bacterial systems: commonalities shared by environmental, laboratory, and clinical microbiologySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.