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Characterization of Self-Assembled Virus-Like Particles of Merkel Cell Polyomavirus

11 Feb 2015

Abstract excerpt

In our recombinant baculovirus system, VP1 protein of merkel cell polyomavirus (MCPyV), which is implicated as a causative agent in Merkel cell carcinoma, was self-assembled into MCPyV-like particles (MCPyV-LP) with two different sizes in insect cells, followed by being released into the culture medium. DNA molecules of 1.5- to 5-kb, which were derived from host insect cells, were packaged in large, ~50-nm...

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PMID: 25671590
DOI: 10.1371/journal.pone.0115646

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