Article
[Impaired epigenetic gene activity regulation and human diseases].
Vestnik Rossiiskoi akademii meditsinskikh nauk - 1 Jan 2001
Nazarenko S A
Abstract excerpt
The epigenetic (i.e. heritable states that are mediated by changes in DNA other than nucleotide sequence) mechanisms of regulation of gene expression have been recently the focus of intensive studies. Genomic imprinting refers to the epigenetic gene marking that results in monoallelic expression. The epigenetic mechanism of imprinting is based on the gamete-specific methylation of some mammalian genes, which...
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