Article
SycE allows secretion of YopE-DHFR hybrids by the Yersinia enterocolitica type III Ysc system.
Molecular microbiology - 1 Nov 2002
Feldman Mario F, Müller Simone, Wüest Esther, Cornelis Guy R
Abstract excerpt
The Ysc type III secretion system allows Yersinia enterocolitica to translocate virulence proteins, called Yop effectors, into the cytosol of eukaryotic cells. Some of the Yop effectors possess an individual chaperone called a Syc protein. The first 15 amino acids of the YopE effector constitute a secretion signal that is sufficient to promote secretion of several reporter proteins. Residues 15-50 of YopE...
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