Duplications of hox gene clusters and the emergence of vertebrates.

doi:10.1016/j.ydbio.2013.03.004

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Article

Duplications of hox gene clusters and the emergence of vertebrates.

Developmental biology - 15 Jun 2013

Soshnikova Natalia, Dewaele Romain, Janvier Philippe, Krumlauf Robb, Duboule Denis

Abstract excerpt

The vertebrate body plan is characterized by an increased complexity relative to that of all other chordates and large-scale gene amplifications have been associated with key morphological innovations leading to their remarkable evolutionary success. Here, we use compound full Hox clusters deletions to investigate how Hox genes duplications may have contributed to the emergence of vertebrate-specific innovations....

Topics

Animals
Body Patterning
Embryo, Mammalian
Evolution, Molecular
Gene Duplication
Gene Expression Regulation, Developmental
Homeodomain Proteins
In Situ Hybridization
Mice
Multigene Family
Mutation
Phylogeny
Vertebrates

Source

Open in PubMed

Identifiers

PMID: 23501471
DOI: 10.1016/j.ydbio.2013.03.004

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