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Article

Inhibition of Androgen Receptor-Mediated Transcription by Amino-Terminal Enhancer of split

1 Jul 2001

Abstract excerpt

A yeast two-hybrid assay has identified an androgen-dependent interaction of androgen receptor (AR) with amino-terminal enhancer of split (AES), a member of the highly conserved Groucho/TLE family of corepressors. Full-length AR, as well as the N-terminal fragment of AR, showed direct interactions with AES in in vitro protein-protein interaction assays. AES specifically inhibited AR-mediated transcription in a...

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PMID: 11416139
DOI: 10.1128/mcb.21.14.4614-4625.2001

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