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Article

Linkage analysis of candidate endothelin pathway genes in nonsyndromic familial orofacial cleft.

Annals of human genetics - 1 Jul 2000

Pezzetti F, Scapoli L, Martinelli M, Carinci F, Brunelli G, Carls F P, Palomba F, Gombos F, Carinci P, Tognon M

Abstract excerpt

There is good evidence from linkage analysis and mouse model knockouts that the endothelin-1 gene (EDN1) is a good candidate for non-syndromic orofacial cleft (OFC) disease. EDN1 maps to the chromosomal region of the OFC1 locus in 6p23. Therefore we have examined three other candidate genes in the endothelin pathway (ECE1, EDNRA and EDNRB, which map to chromosomes 1, 4 and 13 respectively) in a linkage study of 9...

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Source

Identifiers

PMID: 11415518
DOI: 10.1017/S0003480000008216

Genes

EDN1
ECE1
EDNRA
EDNRB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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