Article
Linkage analysis of candidate regions in Swedish nonsyndromic cleft lip with or without cleft palate families.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association - 1 Jul 2000
Wong F K, Hagberg C, Karsten A, Larson O, Gustavsson M, Huggare J, Larsson C, Teh B T, Linder-Aronson S
Abstract excerpt
OBJECTIVE: To analyze linkage of five candidate regions for nonsyndromic cleft lip with or without palate (CLP) on chromosome 2p13, 4q, 6p23, and 19q13; in addition chromosome 1q32, the locus for van der Woude syndrome, on Swedish CLP families. DESIGN: Three to five linked microsatellite markers were selected from each candidate region. Polymerase chain reaction (PCR) with fluorescent-labeled microsatellite...
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