Article
Calcitonin receptor polymorphism is associated with a decreased fracture risk in post-menopausal women.
Human molecular genetics - 1 Dec 1998
Taboulet J, Frenkian M, Frendo J L, Feingold N, Jullienne A, de Vernejoul M C
Abstract excerpt
High bone resorption by the osteoclast results in osteoporosis, a disease affecting 40% of women after the menopause. Calcitonin, used to treat osteoporosis, inhibits bone resorption via receptors located on the osteoclasts. Two alleles of the calcitonin receptor gene ( CTR ) exist: a base mutati...
Topics
- Aged
- Aged, 80 and over
- Alleles
- Amino Acid Substitution
- Analysis of Variance
- Body Weight
- Bone Density
- Cohort Studies
- DNA
- Female
- Fractures, Bone
- Genotype
- HL-60 Cells
- Humans
- Middle Aged
- Osteoporosis, Postmenopausal
- Point Mutation
- Polymerase Chain Reaction