Article
Calcitonin receptor polymorphism is associated with a decreased fracture risk in post-menopausal women.
Human molecular genetics - 1 Dec 1998
Taboulet J, Frenkian M, Frendo J L, Feingold N, Jullienne A, de Vernejoul M C
Abstract excerpt
High bone resorption by the osteoclast results in osteoporosis, a disease affecting 40% of women after the menopause. Calcitonin, used to treat osteoporosis, inhibits bone resorption via receptors located on the osteoclasts. Two alleles of the calcitonin receptor gene ( CTR ) exist: a base mutation T-->C in the third intracellular C-terminal domain changes a proline (CCG) at position 447 to a leucine (CTG). We...
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