Article
High-level expression of a foreign gene from the most 3′-proximal locus of a recombinant Newcastle disease virus
1 Jul 2001
Abstract excerpt
A previous report showed that insertion of a foreign gene encoding chloramphenicol acetyltransferase (CAT) between the HN and L genes of the full-length cDNA of a virulent Newcastle disease virus (NDV) yielded virus with growth retardation and attenuation. The NDV vector used in that study was pathogenic to chickens; it is therefore not suitable for use as a vaccine vector. In the present study, an avirulent NDV...
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