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Article

Somatostatin is required for masculinization of growth hormone-regulated hepatic gene expression but not of somatic growth.

The Journal of clinical investigation - 1 Jun 2001

Low M J, Otero-Corchon V, Parlow A F, Ramirez J L, Kumar U, Patel Y C, Rubinstein M

Abstract excerpt

Pulsatile growth hormone (GH) secretion differs between males and females and regulates the sex-specific expression of cytochrome P450s in liver. Sex steroids influence the secretory dynamics of GH, but the neuroendocrine mechanisms have not been conclusively established. Because periventricular hypothalamic somatostatin (SST) expression is greater in males than in females, we generated knockout (Smst(-/-)) mice...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 11413165
DOI: 10.1172/JCI11941
PMCID: PMC200191

Genes

SST

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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