Article
Nuclear factor-kappaB mediates angiogenesis and metastasis of human bladder cancer through the regulation of interleukin-8.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2003
Karashima Takashi, Sweeney Paul, Kamat Ashish, Huang Suyun, Kim Sun J, Bar-Eli Menashe, McConkey David J, Dinney Colin P N
Abstract excerpt
PURPOSE: Interleukin (IL)-8 is an important mediator of angiogenesis, tumorigenicity, and metastasis in transitional cell carcinoma (TCC) of the bladder. Nuclear factor kappaB (NF-kappaB)/relA regulates IL-8 expression in several neoplasms. The purpose of this study was to determine whether the organ microenvironment (hypoxia, acidosis) regulates the expression of IL-8 in TCC via NF-kappaB, and whether inhibition...
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