Article
Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.
Chemistry & biology - 1 Jan 1999
Prado L, Fernández E, Weissbach U, Blanco G, Quirós L M, Braña A F, Méndez C, Rohr J, Salas J A
Abstract excerpt
BACKGROUND: Mithramycin is a member of the clinically important aureolic acid group of antitumor drugs that interact with GC-rich regions of DNA nonintercalatively. These drugs contain a chromophore aglycon that is derived from condensation of ten acetate units (catalyzed by a type II polyketide...
Topics
- Amino Acid Sequence
- Antibiotics, Antineoplastic
- Carbohydrate Sequence
- Catalysis
- Glycosyltransferases
- Magnetic Resonance Spectroscopy
- Methyltransferases
- Molecular Sequence Data
- Multienzyme Complexes
- Mutagenesis, Insertional
- Mutation
- Oxidation-Reduction
- Oxygenases
- Plicamycin