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Article

Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.

Chemistry & biology - 1 Jan 1999

Prado L, Fernández E, Weissbach U, Blanco G, Quirós L M, Braña A F, Méndez C, Rohr J, Salas J A

Abstract excerpt

BACKGROUND: Mithramycin is a member of the clinically important aureolic acid group of antitumor drugs that interact with GC-rich regions of DNA nonintercalatively. These drugs contain a chromophore aglycon that is derived from condensation of ten acetate units (catalyzed by a type II polyketide synthase). The aglycones are glycosylated at two positions with different chain length deoxyoligosaccharides, which are...

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Identifiers

PMID: 9889148
DOI: 10.1016/s1074-5521(99)80017-9

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Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.PMID 9889148Read ↗

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