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Article

Caspase-dependent cleavage of ErbB-2 by geldanamycin and staurosporin.

The Journal of biological chemistry - 7 Sept 2001

Tikhomirov O, Carpenter G

Abstract excerpt

The geldanamycin-induced degradation of ErbB-2 produces a 23-kDa carboxyl-terminal fragment, which has been isolated and subjected to amino-terminal microsequencing. The obtained sequence indicates that the amino terminus of this fragment corresponds to Gly-1126 of ErbB-2. Analysis of the residues immediately before Gly-1126 suggests that cleavage may involve caspase activity. Site-directed mutagenesis of...

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PMID: 11402024
DOI: 10.1074/jbc.M101394200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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