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Article

Induction of apoptosis and inhibition of c-erbB-2 in MDA-MB-435 cells by genistein.

1 Sept 1999

Abstract excerpt

Breast cancer is the most common cancer and second leading cause of cancer related deaths in women in the United States. Genistein is a protein tyrosine kinase inhibitor and prominent isoflavonoid in soy products and has been proposed as the agent responsible for lowering the rate of breast cancer in Asian women. We have previously shown that genistein inhibits the growth of MDA-MB-231 breast cancer cells,...

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Identifiers

PMID: 10427135
DOI: 10.3892/ijo.15.3.525

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Induction of apoptosis and inhibition of c-erbB-2 in MDA-MB-435 cells by genistein.PMID 10427135Read ↗

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Caspase-3 status is a determinant of the differential responses to genistein between MDA-MB-231 and MCF-7 breast cancer cellsSemantic proximity Read ↗

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Genistein inhibits Brca1 mutant tumor growth through activation of DNA damage checkpoints, cell cycle arrest, and mitotic catastrophe.Semantic proximity Read ↗

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