Article
Effects of pH on the inhibition of fatty acid amidohydrolase by ibuprofen.
British journal of pharmacology - 1 Jun 2001
Holt S, Nilsson J, Omeir R, Tiger G, Fowler C J
Abstract excerpt
The pharmacological properties of fatty acid amidohydrolase (FAAH) at different assay pH values were investigated using [(3)H]-anandamide ([(3)H]-AEA) as substrate in rat brain homogenates and in COS-1 [corrected] cells transfected with wild type and mutant FAAH. Rat brain hydrolysis of [(3)H]-AE...
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