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Article

Susceptibility of p53 unstructured N terminus to 20 S proteasomal degradation programs the stress response.

The Journal of biological chemistry - 25 Sept 2009

Tsvetkov Peter, Reuven Nina, Prives Carol, Shaul Yosef

Abstract excerpt

The N-terminal transcription activation domain of p53 is intrinsically unstructured. We show in vitro and in vivo that this domain initiates p53 degradation by the 20 S proteasome in a ubiquitin-independent fashion. The decay of metabolically labeled p53 follows biphasic kinetics with an immediat...

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Identifiers

PMID: 19617345
DOI: 10.1074/jbc.M109.040493
PMCID: PMC2785311

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19617345-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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