Apoptosis: molecular mechanisms and implications for human disease

Abstract excerpt

Apoptosis is a highly regulated process of cell death with characteristic morphological changes that are distinct from necrosis. The biochemical machinery responsible for apoptotic cell death appears to be constitutively expressed in most, if not all, cells and can be triggered by a variety of signals, including sustained increases in the intracellular Ca2+ level. Apoptosis is the main mechanism of cell deletion...

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