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Article

Lysine 322 in the human IgG3 C(H)2 domain is crucial for antibody dependent complement activation.

Molecular immunology - 1 Nov 2000

Thommesen J E, Michaelsen T E, Løset G Å, Sandlie I, Brekke O H

Abstract excerpt

The classical complement activation cascade of the immune system is initiated by multivalent binding of its first component, C1q, to the Fc region of immunoglobulins in immune complexes. The C1q binding site on mouse IgG2b has been shown to contain the amino acids Glu 318, Lys 320 and Lys 322 in the C(H)2 domain (Duncan, A.R., Winter, G.,1988. The binding site for C1q on IgG. Nature 322 738-740). Identical or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 11395138
DOI: 10.1016/s0161-5890(01)00010-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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