Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The metallochaperone Atox1 plays a critical role in perinatal copper homeostasis.

Proceedings of the National Academy of Sciences of the United States of America - 5 Jun 2001

Hamza I, Faisst A, Prohaska J, Chen J, Gruss P, Gitlin J D

Abstract excerpt

Copper plays a fundamental role in the biochemistry of all aerobic organisms. The delivery of this metal to specific intracellular targets is mediated by metallochaperones. To elucidate the role of the metallochaperone Atox1, we analyzed mice with a disruption of the Atox1 locus. Atox1(-/-) mice failed to thrive immediately after birth, with 45% of pups dying before weaning. Surviving animals exhibited growth...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cation Transport Proteins
Share to Congenital Abnormalities

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Copper

Share to Fetal Death

Share to Fetal Growth Retardation

Share to Molecular Chaperones

Share to Neuropeptides

Source

Open in PubMed Open full text

Identifiers

PMID: 11391006
DOI: 10.1073/pnas.111058498
PMCID: PMC34441

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The metallochaperone Atox1 plays a critical role in perinatal copper homeostasis.PMID 11391006Read ↗

Atox1 contains positive residues that mediate membrane association and aid subsequent copper loading.Semantic proximity Read ↗

The copper transporter CTR1 provides an essential function in mammalian embryonic development.Semantic proximity Read ↗

Tissue localization of the copper chaperone ATOX1 and its potential role in disease.Semantic proximity Read ↗

Metallochaperone Atox1 transfers copper to the NH2-terminal domain of the Wilson's disease protein and regulates its catalytic activity.Semantic proximity Read ↗

Structure-function analyses of the ATX1 metallochaperone.Semantic proximity Read ↗

Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- and cisplatin-binding ecto-domainSemantic proximity Read ↗

Mammalian copper chaperone Cox17p has an essential role in activation of cytochrome C oxidase and embryonic development.Semantic proximity Read ↗

The mouse acrodermatitis enteropathica gene Slc39a4 (Zip4) is essential for early development and heterozygosity causes hypersensitivity to zinc deficiency.Semantic proximity Read ↗

The copper chaperone ATOX1 exhibits differential protein-protein interactions and contributes to skeletal myoblast differentiationSemantic proximity Read ↗

Heart is the most susceptible organ in an isogenic background to loss of function mutations in the mitochondrial metallochaperone SCO1.Semantic proximity Read ↗

The human cytochrome c oxidase assembly factors SCO1 and SCO2 have regulatory roles in the maintenance of cellular copper homeostasis.Semantic proximity Read ↗

Transcriptional profiles and copper stress responses in zebrafish cox17 mutants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.