Article
The 19S regulatory particle of the proteasome is required for efficient transcription elongation by RNA polymerase II.
Molecular cell - 1 May 2001
Ferdous A, Gonzalez F, Sun L, Kodadek T, Johnston S A
Abstract excerpt
It is generally thought that the primary or even sole activity of the 19S regulatory particle of the 26S proteasome is to facilitate the degradation of polyubiquitinated proteins by the 20S-core subunit. However, we present evidence that the 19S complex is required for efficient elongation of RNA polymerase II (RNAP II) in vitro and in vivo. First, yeast strains carrying alleles of SUG1 and SUG2, encoding 19S...
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