Article
AP-3 adaptor functions in targeting P-selectin to secretory granules in endothelial cells.
Traffic (Copenhagen, Denmark) - 1 Jun 2001
Daugherty B L, Straley K S, Sanders J M, Phillips J W, Disdier M, McEver R P, Green S A
Abstract excerpt
P-selectin, a cell adhesion protein participating in the early stages of inflammation, contains multiple sorting signals that regulate its cell surface expression. Targeting to secretory granules regulates delivery of P-selectin to the cell surface. Internalization followed by sorting from early...
Topics
- Adaptor Protein Complex alpha Subunits
- Amino Acid Sequence
- Animals
- Blood Platelets
- CHO Cells
- Cells, Cultured
- Cricetinae
- Cytoplasm
- Endosomes
- Endothelium
- Fibroblasts
- Flow Cytometry