Article
AP-3 adaptor functions in targeting P-selectin to secretory granules in endothelial cells.
Traffic (Copenhagen, Denmark) - 1 Jun 2001
Daugherty B L, Straley K S, Sanders J M, Phillips J W, Disdier M, McEver R P, Green S A
Abstract excerpt
P-selectin, a cell adhesion protein participating in the early stages of inflammation, contains multiple sorting signals that regulate its cell surface expression. Targeting to secretory granules regulates delivery of P-selectin to the cell surface. Internalization followed by sorting from early to late endosomes mediates rapid removal of P-selectin from the surface. We show here that the P-selectin cytoplasmic...
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