Article
The relationship between genetic aberrations as detected by comparative genomic hybridization and vascularization in glioblastoma xenografts.
Journal of neuro-oncology - 1 Jan 2001
Gilhuis H J, Bernse H J, Jeuken J W, Wesselin P, Sprenger S H, Kerstens H M, Wiegant J, Boerman R H
Abstract excerpt
Angiogenesis is of vital importance for the growth of solid tumors and constitutes a target for anti-cancer therapy. Glioblastomas (GBMs) are histologically characterized by striking microvascular proliferation. The identification of the mechanism of angiogenesis is of major importance for the further development of anti-angiogenic therapy. Tumor angiogenesis might be the result of a combination of local tissue...
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