Article
A polymorphism in the human timeless gene is not associated with diurnal preferences in normal adults.
Sleep research online : SRO - 1 Jan 2000
Pedrazzoli M, Ling L, Finn L, Kubin L, Young T, Katzenberg D, Mignot E
Abstract excerpt
The effect of a single nucleotide polymorphism, a glutamine to arginine amino acid substitution in the human Timeless gene (Q831R, A2634G), on diurnal preferences was studied in a random sample of normal volunteers enrolled in a population-based epidemiology study of the natural history of sleep disorders. We genotyped 528 subjects for this single nucleotide polymorphism and determined morningness-eveningness...
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