Article
Screening of clock gene polymorphisms demonstrates association of a PER3 polymorphism with morningness-eveningness preference and circadian rhythm sleep disorder.
Scientific reports - 9 Sept 2014
Hida Akiko, Kitamura Shingo, Katayose Yasuko, Kato Mie, Ono Hiroko, Kadotani Hiroshi, Uchiyama Makoto, Ebisawa Takashi, Inoue Yuichi, Kamei Yuichi, Okawa Masako, Takahashi Kiyohisa, Mishima Kazuo
Abstract excerpt
A system of self-sustained biological clocks controls the 24-h rhythms of behavioral and physiological processes such as the sleep-wake cycle. The circadian clock system is regulated by transcriptional and translational negative feedback loops of multiple clock genes. Polymorphisms in circadian clock genes have been associated with morningness-eveningness (diurnal) preference, familial advanced sleep phase type...
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