Deletion mutation in an eye lens beta-crystallin. An animal model for inherited cataracts.

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Article

Deletion mutation in an eye lens beta-crystallin. An animal model for inherited cataracts.

The Journal of biological chemistry - 15 Apr 1991

Chambers C, Russell P

Abstract excerpt

The most prevalent proteins in the lens of the eye are called crystallins, and it is thought that aberrant crystallins may cause opacification of lens tissue. The Philly mouse, a strain with an inherited cataract, has an abnormal beta B2-crystallin, the principal beta-crystallin in the mouse. The cDNA that codes for the beta B2-crystallin protein has been cloned and sequenced from both the normal and the...

Topics

Amino Acid Sequence
Animals
Base Sequence
Cataract
Chromosome Deletion
Cloning, Molecular
Crystallins
Disease Models, Animal
Gene Library
Lens, Crystalline
Mice
Mice, Mutant Strains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

RNA

Reference Values

Restriction Mapping

Sequence Homology, Nucleic Acid

Source

Open in PubMed

Identifiers

PMID: 1707874

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1707874-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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