Aspartame effect in sickle cell anemia.

doi:10.1067/mcp.2001.115141

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Article

Aspartame effect in sickle cell anemia.

Clinical pharmacology and therapeutics - 1 May 2001

Manion C V, Howard J, Ogle B, Parkhurst J, Edmundson A

Abstract excerpt

OBJECTIVE: To examine the in vitro and in vivo attributes of aspartame and to determine its efficacy for treating sickle cell anemia. RATIONALE: Aspartame (l-aspartyl-l-phenylalanine methyl ester) binds with 2 human Bence Jones proteins. The proteins (Mcg and Sea) showed phenylalanine penetrating into hydrophobic binding sites. This aspartame property suggested a potential to interfere with sickle hemoglobin...

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