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Article

In vitro assembly and recognition of Lys-63 polyubiquitin chains.

The Journal of biological chemistry - 27 Jul 2001

Hofmann R M, Pickart C M

Abstract excerpt

Polyubiquitin chains assembled through lysine 48 (Lys-48) of ubiquitin act as a signal for substrate proteolysis by 26 S proteasomes, whereas chains assembled through Lys-63 play a mechanistically undefined role in post-replicative DNA repair. We showed previously that the products of the UBC13 and MMS2 genes function in error-free post-replicative DNA repair in the yeast Saccharomyces cerevisiae and form a...

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PMID: 11369780
DOI: 10.1074/jbc.M103378200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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In vitro assembly and recognition of Lys-63 polyubiquitin chains.PMID 11369780Read ↗

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