Article
Identification of a chromosome 11q23.2-q24 locus for familial aortic aneurysm disease, a genetically heterogeneous disorder.
Circulation - 22 May 2001
Vaughan C J, Casey M, He J, Veugelers M, Henderson K, Guo D, Campagna R, Roman M J, Milewicz D M, Devereux R B, Basson C T
Abstract excerpt
BACKGROUND: Aortic aneurysms cause significant mortality, and >20% relate to hereditary disorders. Familial aortic aneurysm (FAA) has been described in such conditions as the Marfan and Ehlers-Danlos type IV syndromes, due to defects in the fibrillin-1 and type III procollagen genes, respectively. Other gene defects that cause isolated aneurysms, however, have not thus far been described. METHODS AND RESULTS: We...
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